International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor α, Farnesoid X Receptor β, Liver X Receptor α, Liver X Receptor β, and Vitamin D Receptor

  title={International Union of Pharmacology. LXII. The NR1H and NR1I Receptors: Constitutive Androstane Receptor, Pregnene X Receptor, Farnesoid X Receptor $\alpha$, Farnesoid X Receptor $\beta$, Liver X Receptor $\alpha$, Liver X Receptor $\beta$, and Vitamin D Receptor},
  author={David D. Moore and Shigeaki Kato and Wen Xie and David J. Mangelsdorf and Daniel R. Schmidt and Rui Xiao and Steven A. Kliewer},
  journal={Pharmacological Reviews},
  pages={742 - 759}
The nuclear receptors of the NR1H and NR1I subgroups include the constitutive androstane receptor, pregnane X receptor, farnesoid X receptors, liver X receptors, and vitamin D receptor. The newly emerging functions of these related receptors are under the control of metabolic pathways, including metabolism of xenobiotics, bile acids, cholesterol, and calcium. This review summarizes results of structural, pharmacologic, and genetic studies of these receptors. 

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