International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors

@article{Hamann2015InternationalUO,
  title={International Union of Basic and Clinical Pharmacology. XCIV. Adhesion G Protein–Coupled Receptors},
  author={J{\"o}rg Hamann and Gabriela Aust and Demet Araç and Felix B. Engel and Caroline Formstone and Robert Fredriksson and Randy A. Hall and Breanne L Harty and Christiane Kirchhoff and Barbara Knapp and Arunkumar Krishnan and Ines Liebscher and Hsi-Hsien Lin and David C Martinelli and Kelly R Monk and Miriam C. Peeters and Xianhua Piao and Simone Pr{\"o}mel and Torsten Sch{\"o}neberg and Thue W. Schwartz and Kathleen E. Singer and Martin Stacey and Yuri A Ushkaryov and Mario Vallon and Uwe Wolfrum and Mathew W. Wright and Lei Xu and Tobias Langenhan and Helgi Birgir Schi{\"o}th},
  journal={Pharmacological Reviews},
  year={2015},
  volume={67},
  pages={338 - 367}
}
The Adhesion family forms a large branch of the pharmacologically important superfamily of G protein–coupled receptors (GPCRs). As Adhesion GPCRs increasingly receive attention from a wide spectrum of biomedical fields, the Adhesion GPCR Consortium, together with the International Union of Basic and Clinical Pharmacology Committee on Receptor Nomenclature and Drug Classification, proposes a unified nomenclature for Adhesion GPCRs. The new names have ADGR as common dominator followed by a letter… 
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How recent advances in aGPCR biology could provide the basis for a framework to approach the unique challenges of drug discovery programmes targeting these receptors is discussed.
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TLDR
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The small molecule modulators provide important insights regarding the structure-activity relationship and suggest that targeting the tethered peptide agonist results in a nonselective pharmacological action, while synaptamide may be considered a potentially attractive tool to achieve a higher degree of selectivity.
Adhesion G Protein-Coupled Receptors as Drug Targets for Neurological Diseases.
Specific and direct modulation of the interaction between adhesion GPCR GPR56/ADGRG1 and tissue transglutaminase 2 using synthetic ligands
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This work provides unique tools to modulate aG PCR-ligand binding and establishes a foundation for the development of aGPCR-targeted therapeutics.
Adhesion GPCRs as Modulators of Immune Cell Function.
TLDR
Recent studies revealed intriguing activities of aGPCRs in tolerance induction (EMR1), granulopoiesis (CD97), engulfment of apoptotic cells and bacteria (BAI1), hematopoietic stem cell formation (GPR56), and control of cytotoxicity (G PR56).
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TLDR
Interestingly, specific deregulation was observed in genetically distinct subgroups of AML, thereby identifying different potential therapeutic targets in these frequent AML subgroups.
Adhesion G protein-coupled receptors-Candidate metabotropic mechanosensors and novel drug targets.
  • T. Langenhan
  • Biology, Chemistry
    Basic & clinical pharmacology & toxicology
  • 2019
TLDR
Recent discoveries pertaining to the role of aGPCR as metabotropic mechanosensors that control a large variety of processes in all major tissue types are reviewed.
Adhesion Class GPCRs (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database
TLDR
The nomenclature of these receptors was revised in 2015 as recommended by NC-IUPHAR and the Adhesion GPCR Consortium to include cadherins, immunolobulin, lectins and several receptors have been suggested to function as mechanosensors.
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