International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors.

@article{Klos2013InternationalUO,
  title={International Union of Basic and Clinical Pharmacology. [corrected]. LXXXVII. Complement peptide C5a, C4a, and C3a receptors.},
  author={Andreas Klos and Elisabeth Wende and Kathryn J. Wareham and Peter N Monk},
  journal={Pharmacological reviews},
  year={2013},
  volume={65 1},
  pages={
          500-43
        }
}
The activation of the complement cascade, a cornerstone of the innate immune response, produces a number of small (74-77 amino acid) fragments, originally termed anaphylatoxins, that are potent chemoattractants and secretagogues that act on a wide variety of cell types. These fragments, C5a, C4a, and C3a, participate at all levels of the immune response and are also involved in other processes such as neural development and organ regeneration. Their primary function, however, is in inflammation… CONTINUE READING

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