• Corpus ID: 13115245

International Congress on Hormonal Steroids and Hormones and Cancer The role of vitamin D and retinoids in controlling prostate cancer progression

  title={International Congress on Hormonal Steroids and Hormones and Cancer The role of vitamin D and retinoids in controlling prostate cancer progression},
  author={Donna M. Peehl and David Feldman},
Prostate cancer is a leading cause of cancer-related deaths in many countries. Premalignant lesions and invasive cancer occur more frequently in the prostate than in any organ other than the skin. Yet, the incidence of clinically detected prostate cancer is much lower than the histopathological incidence. The slow growth of prostate cancer and the low incidence of clinically manifest disease in some geographical locations or racial/ethnic groups suggest that prostate cancer can be controlled… 
2 Citations
Pre-clinical evidence and clinical translation of benign prostatic hyperplasia treatment by the vitamin D receptor agonist BXL-628 (Elocalcitol)
The capacity of VDR agonists to treat benign prostatic hyperplasia (BPH), a complex syndrome characterized by a static component related to prostate overgrowth, a dynamic component responsible for urinary irritative symptoms, and a possible inflammatory component, is analysed.


Vitamin D and Prostate Cancer: Biologic Interactions and Clinical Potentials
  • G. Miller
  • Medicine, Biology
    Cancer and Metastasis Reviews
  • 2004
The epidemiological evidence supporting a role for 1,25D deficiency in the genesis of prostatic cancer is reviewed, the effects that this hormone has on benign and malignant prostatic epithelial cells in culture, the mechanisms through which it produces these effects and the potential clinical utility are reviewed.
Vitamin D in the prevention and treatment of prostate cancer.
If treatment with vitamin D would be a viable management alternative for the patient described in the case study is reviewed to determine if it is useful both in the prevention and treatment of prostate cancer.
Vitamin D and prostate cancer.
It is projected that prostate cancer will become the leading cause of cancer and cancer death in men in the United States and for that matter, in the rest of the world as well.
Abnormal level of retinoic acid in prostate cancer tissues.
It is shown that normal prostate, benign prostate hyperplasia, and prostate carcinoma tissues contain endogenous retinol and its biologically active metabolite retinoic acid.
Retinoids in cancer chemoprevention
  • R. Lotan
  • Medicine, Biology
    FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 1996
Retinoids are potentially useful agent for cancer chemoprevention and appear to be associated with the ability of retinoids to modulate the growth, differentiation, and apoptosis of normal, premalignant, and malignant cells in vitro and in vivo.
Vitamin D receptor expression as a predictive marker of biological behavior in human colorectal cancer.
This work measured vitamin D receptor (VDR) expression in 75 human colorectal cancers as a potential predictive marker of the biological behavior of the disease and showed that a high level of VDR expression was associated with a favorable prognosis.
The role of vitamin D in normal prostate growth and differentiation.
In the absence of testosterone, 1,25 D may exert a growth-promoting effect on the prostatic stroma in vivo, and in concert with testosterone, it may play an important role in the growth and differentiation of the normal rat prostate.
A selective retinoid with high activity against an androgen‐resistant prostate cancer cell type
It is shown that a synthetic retinoid, CD‐271, that activates selectively the RARγ subtype in a given context, shows increased anti‐proliferative activity against certain carcinoma cells over all‐trans‐retinoic acid (tRA).
Combination of phenylbutyrate and 13-cis retinoic acid inhibits prostate tumor growth and angiogenesis.
An additive inhibitory effect of combination of differentiation agents PB and CRA on prostate tumor growth through a direct effect on both tumor and endothelial cells is shown.
Is vitamin D deficiency a risk factor for prostate cancer? (Hypothesis).
It is hypothesized that Vitamin (Hormone) D deficiency may underlie the major risks for prostate cancer, including age, Black race, and northern latitudes, which are associated with decreased synthesis of Vitamin D.