Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients.

@article{Reubi2010InternalizedSR,
  title={Internalized somatostatin receptor subtype 2 in neuroendocrine tumors of octreotide-treated patients.},
  author={Jean Claude Reubi and Beatrice Waser and Renzo Cescato and Beat Gloor and Christoph Stettler and Emanuel R. Christ},
  journal={The Journal of clinical endocrinology and metabolism},
  year={2010},
  volume={95 5},
  pages={
          2343-50
        }
}
CONTEXT Somatostatin receptor subtype 2 (sst(2)) is widely expressed in neuroendocrine tumors and can be visualized immunohistochemically at the cell membrane for diagnostic purposes. Recently, it has been demonstrated in animal sst(2) tumor models in vivo that somatostatin analog treatment was able to induce a complete internalization of the tumor sst(2). PATIENTS AND METHODS In the present study, we evaluated whether sst(2) expressed in neuroendocrine tumors of patients treated with… CONTINUE READING

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