Internalized Pseudomonas exotoxin A can exploit multiple pathways to reach the endoplasmic reticulum.

@article{Smith2006InternalizedPE,
  title={Internalized Pseudomonas exotoxin A can exploit multiple pathways to reach the endoplasmic reticulum.},
  author={Daniel Smith and Robert A. Spooner and P Watson and James L. Murray and Thomas W Hodge and Mohamed Amessou and Ludger Johannes and John Michael Lord and Lynne M. Roberts},
  journal={Traffic},
  year={2006},
  volume={7 4},
  pages={379-93}
}
Receptor-mediated internalization to the endoplasmic reticulum (ER) and subsequent retro-translocation to the cytosol are essential sequential processes required for the intoxication of mammalian cells by Pseudomonas exotoxin A (PEx). The toxin binds the alpha2-macroglobulin receptor/low-density lipoprotein receptor-related protein. Here, we show that in HeLa cells, PEx recruits a proportion of this receptor to detergent-resistant microdomains (DRMs). Uptake of receptor-bound PEx involves… CONTINUE READING

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