Internalization of sex hormone-binding globulin into neurons and brain cells in vitro and in vivo.

@article{Caldwell2007InternalizationOS,
  title={Internalization of sex hormone-binding globulin into neurons and brain cells in vitro and in vivo.},
  author={Jack Daniel Caldwell and Robert A Shapiro and Gustav Friedrich Jirikowski and Farhana Suleman},
  journal={Neuroendocrinology},
  year={2007},
  volume={86 2},
  pages={84-93}
}
BACKGROUND Sex hormone-binding globulin (SHBG) is a 94-kDa homodimer that binds steroids and is made in the hypothalamus. We have demonstrated that infusions of SHBG into the hypothalami of rats increase their female sexual receptivity except when SHBG is coupled to dihydrotestosterone (DHT) suggesting that SHBG has an active function in behavioral neuroendocrinology. METHODS This study examines the possibility that SHBG is internalized by neuronal and/or non-neuronal brain cells as one… CONTINUE READING