Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor

@article{Robb1987InternalizationOI,
  title={Internalization of interleukin 2 is mediated by the beta chain of the high-affinity interleukin 2 receptor},
  author={Richard J. Robb and Warner C. Greene},
  journal={The Journal of Experimental Medicine},
  year={1987},
  volume={165},
  pages={1201 - 1206}
}
High-affinity IL-2-R correspond to a membrane receptor complex composed of two different IL-2-binding proteins, the Tac antigen (alpha chain) and a 70-75 kD beta chain. Using cell lines that express either the alpha or the beta protein, we demonstrate that IL-2 internalization occurs when ligand is bound to the isolated beta chain, but not when it is bound to the isolated alpha chain. The kinetics of IL-2 internalization mediated by the intermediate-affinity beta chain were nearly identical to… CONTINUE READING

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T-cell growth factor : purification, interaction with a cellular receptor, and in vitro synthesis

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