Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.

  title={Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.},
  author={Graça Raposo and Irene Dunia and Colette Delavier-Klutchko and Srini Kaveri and Arthur Donny Strosberg and Ennio Lucio Benedetti},
  journal={European journal of cell biology},
  volume={50 2},
To characterize the mechanism of internalization of beta-adrenergic catecholamine receptors on human epidermoid A431 carcinoma cells, their distribution was analyzed by immunocytochemistry using the monoclonal anti-receptor antibody BRK2. In preconfluent cultures, the receptors appeared to be randomly distributed on the cell surface. Exposure to the agonist isoproterenol induced an overall decrease in the number of cell surface receptors as determined by binding experiments and visualized by… CONTINUE READING


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