Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection.

@article{Zsengeller2000InternalizationOA,
  title={Internalization of adenovirus by alveolar macrophages initiates early proinflammatory signaling during acute respiratory tract infection.},
  author={Zsuzsanna K Zsengeller and Kaori Otake and Shaikh Abu Hossain and Pierre Yves Berclaz and Bruce C. Trapnell},
  journal={Journal of virology},
  year={2000},
  volume={74 20},
  pages={9655-67}
}
Adenovirus is a common respiratory pathogen which causes a broad range of distinct clinical syndromes and has recently received attention for its potential for in vivo gene delivery. Although adenovirus respiratory tract infection (ARTI) results in dose-dependent, local inflammation, the pathogenesis of this remains unclear. We hypothesized that alveolar macrophages (AMphi) rapidly internalize adenovirus following in vivo pulmonary administration and then initiate inflammatory signaling within… CONTINUE READING
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