Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis

@article{Kima2000InternalizationOL,
  title={Internalization of Leishmania mexicana Complex Amastigotes via the Fc Receptor Is Required to Sustain Infection in Murine Cutaneous Leishmaniasis},
  author={Peter E Kima and Stephanie L. Constant and Lynn G. Hannum and Mar{\'i}a Colmenares and Karen S. Lee and Ann M. Haberman and Mark J. Shlomchik and Diane McMahon-Pratt},
  journal={The Journal of Experimental Medicine},
  year={2000},
  volume={191},
  pages={1063 - 1068}
}
We show here that maintenance of Leishmania infections with Leishmania mexicana complex parasites (Leishmania amazonensis and Leishmania pifanoi) is impaired in the absence of circulating antibody. In these studies, we used mice genetically altered to contain no circulating antibody, with and without functional B cells. This experimental design allowed us to rule out a critical role for B cell antigen presentation in Leishmania pathogenesis. In addition, we show that mice lacking the common… CONTINUE READING
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