Internalization of IgG-coated targets results in activation and secretion of soluble CD40 ligand and RANTES by human platelets.

@article{Antczak2011InternalizationOI,
  title={Internalization of IgG-coated targets results in activation and secretion of soluble CD40 ligand and RANTES by human platelets.},
  author={Adam J Antczak and Joshua A. Vieth and Navinderjit Singh and Randall G Worth},
  journal={Clinical and vaccine immunology : CVI},
  year={2011},
  volume={18 2},
  pages={210-6}
}
Platelets are crucial elements for maintenance of hemostasis. Other functions attributable to platelets are now being appreciated, such as their role in inflammatory reactions and host defense. Platelets have been reported to bind immunological stimuli like IgG complexes, and for nearly 50 years it has been speculated that platelets may participate in immunological reactions. Platelets have been reported to bind and internalize various substances, similar to other leukocytes, such as… CONTINUE READING