Internalization of Echovirus 1 in Caveolae

@article{Marjomki2002InternalizationOE,
  title={Internalization of Echovirus 1 in Caveolae},
  author={V. Marjom{\"a}ki and V. Pieti{\"a}inen and Heli Matilainen and P. Upla and J. Ivaska and L. Nissinen and H. Reunanen and P. Huttunen and T. Hyypiä and J. Heino},
  journal={Journal of Virology},
  year={2002},
  volume={76},
  pages={1856 - 1865}
}
ABSTRACT Echovirus 1 (EV1) is a human pathogen which belongs to the Picornaviridae family of RNA viruses. We have analyzed the early events of infection after EV1 binding to its receptor α2β1 integrin and elucidated the route by which EV1 gains access to the host cell. EV1 binding onto the cell surface and subsequent entry resulted in conformational changes of the viral capsid as demonstrated by sucrose gradient sedimentation analysis. After 15 min to 2 h postinfection (p.i.) EV1 capsid… Expand
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