Internalization of Clostridium perfringens α-toxin leads to ERK activation and is involved on its cytotoxic effect.

@article{MonturiolGross2014InternalizationOC,
  title={Internalization of Clostridium perfringens α-toxin leads to ERK activation and is involved on its cytotoxic effect.},
  author={Laura Monturiol-Gross and Marietta Flores-D{\'i}az and Diana Campos-Rodr{\'i}guez and Rodrigo Mora and Mariela Rodr{\'i}guez-Vega and David L. Marks and Alberto Alape-Gir{\'o}n},
  journal={Cellular microbiology},
  year={2014},
  volume={16 4},
  pages={535-47}
}
Clostridium perfringens phospholipase C (CpPLC), also called α-toxin, plays a key role in the pathogenesis of gas gangrene. CpPLC may lead to cell lysis at concentrations that cause extensive degradation of plasma membrane phospholipids. However, at sublytic concentrations it induces cytotoxicity without inducing evident membrane damage. The results of this work demonstrate that CpPLC becomes internalized in cells by a dynamin-dependent mechanism and in a time progressive process: first, CpPLC… CONTINUE READING

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