Internalization of CD40 regulates its signal transduction in vascular endothelial cells.

@article{Chen2006InternalizationOC,
  title={Internalization of CD40 regulates its signal transduction in vascular endothelial cells.},
  author={Yali Chen and Jianjun Chen and Yanbao Xiong and Qi Da and Youli Xu and Xuejun Jiang and Hong Tang},
  journal={Biochemical and biophysical research communications},
  year={2006},
  volume={345 1},
  pages={106-17}
}
The CD40 ligand (CD40L)-CD40 dyad can ignite proinflammatory and procoagulatory activities of the vascular endothelium in the pathogenesis and progression of atherosclerosis. Besides being expressed on the activated CD4(+) T cell surface (mCD40L), the majority of circulating CD40L reservoir (sCD40L) in plasma is released from stimulated platelets. It remains debatable which form of CD40L triggers endothelial inflammation. Here, we demonstrate that the agonistic antibody of CD40 (G28.5), which… CONTINUE READING