Internalization and signal transduction of PrP(106-126) in neuronal cells.


Invasion of the nervous system and neuronal spread of infection are critical, but poorly understood steps in the pathogenesis of prion diseases. We have thus analyzed the internalization and signal transduction of the neurotoxic fragment of the prion protein PrP(106-126) in the rat neuroblastoma cell line B104 by fluorescence microscopy and quantification… (More)
DOI: 10.1016/j.aanat.2009.06.003


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