Internalization and rapid recycling of macrophage Fc receptors tagged with monovalent antireceptor antibody: possible role of a prelysosomal compartment

@article{Mellman1984InternalizationAR,
  title={Internalization and rapid recycling of macrophage Fc receptors tagged with monovalent antireceptor antibody: possible role of a prelysosomal compartment},
  author={Ira Mellman and Helen Plutner and Pentti Ukkonen},
  journal={The Journal of Cell Biology},
  year={1984},
  volume={98},
  pages={1163 - 1169}
}
Binding and pinocytosis of polyvalent IgG-containing immune complexes by mouse macrophages leads to the selective removal of Fc receptors (FcR) from the cell surface and to the rapid delivery of receptor and ligand to lysosomes, where both are degraded (I. Mellman and H. Plutner, 1984, Journal of Cell Biology, 98:1170-1177). In this paper, we have studied the internalization of FcR tagged with a monovalent probe that, unlike IgG-complexes, cannot cross-link adjacent receptors. We have used an… CONTINUE READING

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