Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2.

@article{Shih1994InternalizationAI,
  title={Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2.},
  author={Lisa B. Shih and H. H. Lu and H. Xuan and David M. Goldenberg},
  journal={International journal of cancer},
  year={1994},
  volume={56 4},
  pages={538-45}
}
The successful clinical experience with antibody LL2 (an IgG2a, anti-B-cell lymphoma antibody) in radioimmunodetection and radioimmunotherapy suggests that this antibody may have potential as a carrier of cytotoxic agents. The internalization, cellular trafficking, and catabolism of this antibody in target human Burkitt lymphoma cells (Raji) were investigated. Internalization of intact antibody as well as of the F(ab')2 and Fab' fragments was detected by an FITC-labeled anti-mouse second… CONTINUE READING

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