Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.

@article{Minami1987InternalizationAC,
  title={Internalization and cycling of the T cell antigen receptor. Role of protein kinase C.},
  author={Yasuhiro Minami and Lawrence E Samelson and Richard D. Klausner},
  journal={The Journal of biological chemistry},
  year={1987},
  volume={262 27},
  pages={13342-7}
}
The dynamics of the T cell antigen receptor on a murine antigen specific T cell hybridoma have been analyzed using a monoclonal anti-receptor antibody. When this antibody, A2B4-2, is bound to surface receptors, no internalization is seen at 4 degrees C. Upon warming to 37 degrees C, between 20 and 30% of the antibody molecules are internalized over 20-30 min as measured by sensitivity to external acid. This level of internalization is identical if monovalent Fab fragments are used. In contrast… CONTINUE READING

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