Internal translation initiation of picornaviruses and hepatitis C virus.

  title={Internal translation initiation of picornaviruses and hepatitis C virus.},
  author={Michael Niepmann},
  journal={Biochimica et biophysica acta},
  volume={1789 9-10},
Picornaviruses and other positive-strand RNA viruses like hepatitis C virus (HCV) enter the cell with a single RNA genome that directly serves as the template for translation. Accordingly, the viral RNA genome needs to recruit the cellular translation machinery for viral protein synthesis. By the use of internal ribosome entry site (IRES) elements in their genomic RNAs, these viruses bypass translation competition with the bulk of capped cellular mRNAs and, moreover, establish the option to… CONTINUE READING
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