Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia

Abstract

We analyzed tandem duplication in the juxtamembrane (JM) domain of the FLT3 (FMS-like tyrosine kinase 3/FLK2, CD135) gene in 94 children with acute myeloid leukemia (AML) and evaluated its correlation with clinical features. Longer polymerase chain reaction (PCR) products were observed in five patients; 1/3 of M0, 1/9 of M1, 1/39 of M2, 1/9 of M3 and 1/12… (More)
DOI: 10.1038/sj.leu.2401241

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@article{Iwai1999InternalTD, title={Internal tandem duplication of the FLT3 gene and clinical evaluation in childhood acute myeloid leukemia}, author={Takehisa Iwai and Shunpei Yokota and Minoru Nakao and Takeshi Okamoto and Masafumi Taniwaki and Norio Onodera and Akiharu Watanabe and Atsushi Kikuta and Akio Tanaka and Koji Asami and Ikuo Sekine and Hideo Mugishima and Yukio Nishimura and Shinji Koizumi and Yasuo Horikoshi and Junichi Mimaya and Shoichiro Ohta and Kiyonobu Nishikawa and Atsuhiro Iwai and Takayoshi Shimokawa and Masayasu Nakayama and Kazuyoshi Kawakami and Takeshi Gushiken and Nobuyuki Hyakuna and Naoyuki Katano and Masahito Tsurusawa and Takashi Fujimoto}, journal={Leukemia}, year={1999}, volume={13}, pages={38-43} }