Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia

Abstract

FLT3 is a member of receptor tyrosine kinases expressed in leukemia cells, as well as in hematopoietic stem cells. Recently, a somatic alteration of the FLT3 gene was found in acute myeloid leukemia, as an internal tandem duplication (FLT3/ITD) which caused elongation of the juxtamembrane (JM) domain of FLT3. Here we characterized the FLT3/ITD and… (More)
DOI: 10.1038/sj.leu.2400756

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