Internal tandem duplication mutation of FLT3 blocks myeloid differentiation through suppression of C/EBP expression


Constitutively activating mutations of FMS-like tyrosine kinase 3 (FLT3) occur in approximately one third of patients with acute myeloid leukemia (AML) and are associated with poor prognosis. Altered FLT3 signaling leads to antiapoptotic and proliferative signaling pathways. We recently showed that these mutations can also contribute to the differentiation… (More)


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Citations per Year

Citation Velocity: 6

Averaging 6 citations per year over the last 3 years.

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