Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos.

@article{Hernndez2004InternalRE,
  title={Internal ribosome entry site drives cap-independent translation of reaper and heat shock protein 70 mRNAs in Drosophila embryos.},
  author={Greco Hern{\'a}ndez and Paula Vazquez-Pianzola and Jos{\'e} Manuel Sierra and Rolando Rivera-Pomar},
  journal={RNA},
  year={2004},
  volume={10 11},
  pages={
          1783-97
        }
}
Translation is a sensitive regulatory step during cellular stress and the apoptosis response. Under such conditions, cap-dependent translation is reduced and internal ribosome entry site (IRES)-dependent translation plays a major role. However, many aspects of how mRNAs are translated under stress remain to be elucidated. Here we report that reaper mRNA, a pro-apoptotic gene from Drosophila melanogaster, is translated in a cap-independent manner. In Drosophila mutant embryos devoid of the… 

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