Internal ribosomal entry site (IRES) activity generates endogenous carboxyl-terminal domains of Cx43 and is responsive to hypoxic conditions.

@article{ulHussain2014InternalRE,
  title={Internal ribosomal entry site (IRES) activity generates endogenous carboxyl-terminal domains of Cx43 and is responsive to hypoxic conditions.},
  author={Mahboob ul-Hussain and Stephan Olk and Bodo Schoenebeck and Bianca Wasielewski and Carola Meier and Nora Prochnow and Caroline May and Sara Galozzi and Katrin Marcus and Georg Zoidl and Rolf Dermietzel},
  journal={The Journal of biological chemistry},
  year={2014},
  volume={289 30},
  pages={20979-90}
}
Connexin43 (Cx43) is the most abundant gap junction protein in higher vertebrate organisms and has been shown to be involved in junctional and non-junctional functions. In addition to the expression of full-length Cx43, endogenously produced carboxyl-terminal segments of Cx43 have been described and have been suggested to be involved in manifold biological functions, such as hypoxic preconditioning and neuronal migration. Molecular aspects, however, behind the separate generation of carboxyl… CONTINUE READING
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