Internal prostaglandin synthesis augments osteoprotegerin production in human gingival fibroblasts stimulated by lipopolysaccharide.

@article{Kiji2007InternalPS,
  title={Internal prostaglandin synthesis augments osteoprotegerin production in human gingival fibroblasts stimulated by lipopolysaccharide.},
  author={Makoto Kiji and Toshiyuki Nagasawa and Doosadee Hormdee and Reiko Yashiro and Hiroaki Kobayashi and K. Noguchi and Hiroyuki Nitta and Yuichi Izumi and Isao Ishikawa},
  journal={Clinical and experimental immunology},
  year={2007},
  volume={149 2},
  pages={327-34}
}
Periodontitis is an inflammatory bone disease caused by Gram-negative anaerobic bacteria. Osteoclast differentiation is regulated by the balance between receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG). The purpose of this study was to examine the mechanism of OPG production in human gingival fibroblasts (HGF) stimulated by lipopolysaccharide (LPS) from periodontopathic bacteria. The expressions of Toll-like receptor 2 (TLR-2) and TLR-4 in HGF were examined… CONTINUE READING

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