Internal friction of compressed pharmaceutical powders observed in terms of the die wall pressure.

  title={Internal friction of compressed pharmaceutical powders observed in terms of the die wall pressure.},
  author={Tomoaki Fukuda and Yoshinobu Fukumori and Shinji Wada and Y Hanyu},
  journal={Chemical \& pharmaceutical bulletin},
  volume={28 2},
The internal friction of powders was examined during tablet preparation for lactose and phenacetin as base materials and for potassium chloride, potassium bromide and sodium chloride as model samples. The coefficient of internal friction decreased with the porosity, even if the voids were filled by fragmentation of particles or by plastic flow. When the porosity had reached zero, the state of the whole bed of powder was found to be plastic, where the coefficient of internal friction was zero… 
Study of radial die-wall pressure during high speed tableting: effect of formulation variables
The effects of common formulation factors such as lubricant, binder, and drug loading on RDW were investigated and die-wall instrumentation was useful in investigating formulation variables and detecting capping during high speed tableting.
Instrumentation of tableting machines : high speed compaction investigation through simulation and radial die-wall pressure monitoring
Background: The complexity of the compaction process specially with using high-speed tablet presses necessitates the use of robust monitoring tools during the process. The use of an instrumented
Lubrication in tablet formulations.
  • Jennifer J Wang, Hong Wen, D. Desai
  • Chemistry
    European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
  • 2010
Direct compaction: An update of materials, trouble-shooting, and application.