Internal exposure of rats to benzidine derived from orally administered benzidine-based dyes after intestinal azo reduction.

@article{Bos1986InternalEO,
  title={Internal exposure of rats to benzidine derived from orally administered benzidine-based dyes after intestinal azo reduction.},
  author={R. P. Bos and W M Van der Krieken and L J Smeijsters and Jan Pieter R. Koopman and Hugo R. de Jonge and J L Theuws and Paul T Henderson},
  journal={Toxicology},
  year={1986},
  volume={40 2},
  pages={207-13}
}
The role of the rat intestinal flora in the azo reduction of some benzidine-based dyes was studied in vitro and in vivo. The formation of benzidine was measured after anaerobic incubation of direct black 38, direct blue 6 and direct brown 95 in the presence of caecal bacteria in vitro. Benzidine was absorbed from the intestinal tract much better than the… CONTINUE READING