Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade

@article{Palmer2020InternalCR,
  title={Internal checkpoint regulates T cell neoantigen reactivity and susceptibility to PD1 blockade},
  author={Douglas C. Palmer and Beau R. Webber and Yogin Patel and Matthew J. Johnson and Christine M. Kariya and Walker S. Lahr and Maria R Parkhurst and Jared J. Gartner and Todd D Prickett and Frank J. Lowery and Rigel J. Kishton and Devikala Gurusamy and Zulmarie Franco and Suman Kumar Vodnala and Miechaleen D. Diers and Natalie K. Wolf and Nicholas J. Slipek and David H. McKenna and Darin Sumstad and Lydia Viney and Tom Henley and Tilmann B{\"u}rckst{\"u}mmer and Oliver Baker and Ying Hu and Chunhua Yan and Daoud M. Meerzaman and Kartika Padhan and Branden S. Moriarity and Winifred M. Lo and Parisa Malekzadeh and Li Jia and Drew C. Deniger and Shashank J. Patel and Paul F. Robbins and R Scott McIvor and Modassir Choudhry and Nicholas P. Restifo and Steven A. Rosenberg},
  journal={bioRxiv},
  year={2020}
}
While neoantigen-specific tumor infiltrating lymphocytes (TIL) can be derived from in antigen-expressing tumors, their adoptive transfer fails to consistently elicit durable tumor regression. There has been much focus on the role of activation/exhaustion markers such as PD1, CD39 and TOX in TIL senescence. We found these markers were inversely expressed to Cytokine-Induced SH2 protein (CISH), a negative regulator of TCR signaling and tumor immunity in mice. To evaluate the physiological role of… 

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