Internal and external differentiations of the postsynaptic membrane at the neuromuscular junction.

@article{Hirokawa1982InternalAE,
  title={Internal and external differentiations of the postsynaptic membrane at the neuromuscular junction.},
  author={Nobutaka Hirokawa and John E. Heuser},
  journal={Journal of neurocytology},
  year={1982},
  volume={11 3},
  pages={
          487-510
        }
}
Frog, snake and rat neuromuscular junctions were prepared for electron microscopy by the quick-freeze, deep-etch, rotary replication procedure. The postsynaptic membrane was exposed by treating muscles with 1 mg/ml collagenase to remove the basal lamina. Present on the apices of the postsynaptic folds are regular arrays of 8-9 nm protrusions. These are not seen in the depths of the folds nor elsewhere on the muscle surface, thus they presumably represent the heads of cholinergic receptor… CONTINUE READING
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