Internal Multiple-Scattering Hole-Enhanced Raman Spectroscopy: Improved Backscattering Fourier Transform Raman Sampling in Pharmaceutical Tablets Utilizing Cylindrical–Conical Holes

@article{Larkin2012InternalMH,
  title={Internal Multiple-Scattering Hole-Enhanced Raman Spectroscopy: Improved Backscattering Fourier Transform Raman Sampling in Pharmaceutical Tablets Utilizing Cylindrical–Conical Holes},
  author={P. Larkin and Matthew Santangelo and S. {\vS}a{\vs}iċ},
  journal={Applied Spectroscopy},
  year={2012},
  volume={66},
  pages={892 - 902}
}
The benefits of Raman signal enhancement and improved measurement precision are demonstrated using 180° backscattering Fourier transform Raman (FT-Raman) spectroscopy from drilled cylindrical–conical holes within pharmaceutical tablet cores. Multiple scattering of the incident laser light within the holes results in an increased Raman signal due to the larger Raman sampling volume. This is important for overcoming typical sub-sampling issues encountered when employing FT-Raman backscattering of… Expand
6 Citations
Optimizing laser crater enhanced Raman scattering spectroscopy.
Raman spectroscopy as a process analytical technology for pharmaceutical manufacturing and bioprocessing
Predicting final product properties of melt extruded solid dispersions from process parameters using Raman spectrometry.

References

SHOWING 1-10 OF 43 REFERENCES
Transmission Fourier Transform Raman Spectroscopy of Pharmaceutical Tablet Cores
Bulk Raman Analysis of Pharmaceutical Tablets
Non-invasive quantitative assessment of the content of pharmaceutical capsules using transmission Raman spectroscopy.
Quantitative Transmission Raman Spectroscopy of Pharmaceutical Tablets and Capsules
Quantitative study of self‐absorption in near‐infrared Fourier transform Raman spectroscopy
Raman Signal Enhancement in Deep Spectroscopy of Turbid Media
...
1
2
3
4
5
...