Internal Friction as a Possible Key Factor Governing the Thermosensitivity of TRP Channels

  title={Internal Friction as a Possible Key Factor Governing the Thermosensitivity of TRP Channels},
  author={A. O. Okenov and Bogdan I. Iaparov and Alexander S. Moskvin},
  journal={JETP Letters},
Six thermo-activated transient receptor potential (TRP) channels are the molecular basis of the thermosensation for mammals. However, the molecular source of their gating remains unknown. In the Letter, we suggest a physically based model for the TRP channels and show that the temperature dependence of the “internal friction” can be a key factor governing the ion channels gating. Results of the computer modeling allowed us to successfully reproduce the experimental data for the open probability… 

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