Internal Dynamics Determine the Cortical Response to Thalamic Stimulation

  title={Internal Dynamics Determine the Cortical Response to Thalamic Stimulation},
  author={Jason N. MacLean and Brendon O. Watson and Gloster B. Aaron and Rafael Yuste},
Although spontaneous activity occurs throughout the neocortex, its relation to the activity produced by external or sensory inputs remains unclear. To address this, we used calcium imaging of mouse thalamocortical slices to reconstruct, with single-cell resolution, the spatiotemporal dynamics of activity of layer 4 in the presence or absence of thalamic stimulation. We found spontaneous neuronal coactivations corresponded to intracellular UP states. Thalamic stimulation of sufficient frequency… CONTINUE READING
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