Internal/structures containing transcriptase-related proteins in top component particles of mammalian orthoreovirus.

  title={Internal/structures containing transcriptase-related proteins in top component particles of mammalian orthoreovirus.},
  author={Kelly Dryden and Diane L. Farsetta and Gongbo Wang and Joshua M. Keegan and Bernard Nathan Fields and Timothy S. Baker and Max L Nibert},
  volume={245 1},
The structure of mammalian orthoreovirus top component particles, which are profoundly deficient in the content of double-stranded RNA genome, was determined at 30 A resolution by transmission cryoelectron microscopy and three-dimensional image reconstruction. Previously undetected, ordered densities, appearing primarily as pentameric flowers in the reconstruction, were seen to extend 65 A inwardly from the inner capsid at the icosahedral fivefold axes. Identically positioned but lower density… CONTINUE READING


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