Intermolecular interactions of Sprouty proteins and their implications in development and disease.

@article{Edwin2009IntermolecularIO,
  title={Intermolecular interactions of Sprouty proteins and their implications in development and disease.},
  author={Francis Edwin and Kimberly Anderson and Chunyi Ying and Tarun B. Patel},
  journal={Molecular pharmacology},
  year={2009},
  volume={76 4},
  pages={679-91}
}
Receptor tyrosine kinase (RTK) signaling is spatially and temporally regulated by a number of positive and negative regulatory mechanisms. These regulatory mechanisms control the amplitude and duration of the signals initiated at the cell surface to have a normal or aberrant biological outcome in development and disease, respectively. In the past decade, the Sprouty (Spry) family of proteins has been identified as modulators of RTK signaling in normal development and disease. This review… CONTINUE READING