Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis.

@article{Koshkin2004IntermolecularII,
  title={Intermolecular interactions in the AhpC/AhpD antioxidant defense system of Mycobacterium tuberculosis.},
  author={Aleksey Koshkin and Giselle M. Knudsen and Paul R. Ortiz de Montellano},
  journal={Archives of biochemistry and biophysics},
  year={2004},
  volume={427 1},
  pages={41-7}
}
The AhpC/AhpD system of Mycobacterium tuberculosis provides important antioxidant protection, particularly when the KatG catalase-peroxidase activity is depressed, as it is in many isoniazid resistant strains. In the absence of lipoamide or bovine dihydrolipoamide dehydrogenase (DHLDH), components of the normal catalytic system, covalent dimers, tetramers, and hexamers are formed when a mixture of AhpC and AhpD is exposed to peroxide. Each of the oligomers contains equimolar amounts of AhpC and… CONTINUE READING

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