Intermolecular interactions between peptidic and nonpeptidic agonists and the third extracellular loop of the cholecystokinin 1 receptor.

@article{Giragossian2003IntermolecularIB,
  title={Intermolecular interactions between peptidic and nonpeptidic agonists and the third extracellular loop of the cholecystokinin 1 receptor.},
  author={Craig Giragossian and Elizabeth Ellen Sugg and Jerzy Ryszard Szewczyk and Dale F. Mierke},
  journal={Journal of medicinal chemistry},
  year={2003},
  volume={46 16},
  pages={
          3476-82
        }
}
Intermolecular interactions were determined between a synthetic peptide corresponding to the third extracellular loop and several residues from the adjoining sixth and seventh transmembrane domains of the human cholecystokinin-1 receptor, CCK(1)-R(329-357), and the synthetic agonists Ace-Trp-Lys[NH(epsilon)CONH-o-(MePh)]-Asp-MePhe-NH(2) (GI5269) and the C1 N-isopropyl-N-(4-methoxyphenyl)acetamide derivative of 3-(1H-Indazol-3ylmethyl)-3-methyl-5-pyridin-3-yl-1,5-benzodiazepine (GI0122), using… 

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How does cholecystokinin stimulate exocrine pancreatic secretion? From birds, rodents, to humans.

  • B. J. WangZ. Cui
  • Biology
    American journal of physiology. Regulatory, integrative and comparative physiology
  • 2007
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