Intermolecular disulfide bonds between nucleoporins regulate karyopherin-dependent nuclear transport.

Abstract

Disulfide (S-S) bonds play important roles in the regulation of protein function and cellular stress responses. In this study, we demonstrate that distinct sets of nucleoporins (Nups), components of the nuclear pore complex (NPC), form S-S bonds and regulate nuclear transport through the NPC. Kinetic analysis of importin β demonstrated that the permeability… (More)
DOI: 10.1242/jcs.124172

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