Intermolecular Alignment in Beta 2-Microglobulin Amyloid Fibrils

@inproceedings{Debelouchina2010IntermolecularAI,
  title={Intermolecular Alignment in Beta 2-Microglobulin Amyloid Fibrils},
  author={Galia T Debelouchina and Marvin J. Bayro and Sheena E Radford and Robert G Griffin and Geoffrey W. Platt},
  year={2010}
}
The deposition of amyloid-like fibrils, composed primarily of the 99-residue protein 2-microglobulin ( 2m), is one of the characteristic symptoms of dialysis-related amyloidosis. Fibrils formed in vitro at low pH and low salt concentration share many properties with the disease related fibrils and have been extensively studied by a number of biochemical and biophysical methods. These fibrils contain a significant -sheet core and have a complex cryoEM electron density profile. Here, we… CONTINUE READING

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