Intermittent versus continuous administration of 1,25-dihydroxyvitamin D3 in experimental renal hyperparathyroidism.

@article{Reichel1993IntermittentVC,
  title={Intermittent versus continuous administration of 1,25-dihydroxyvitamin D3 in experimental renal hyperparathyroidism.},
  author={Helmut Reichel and Andr{\'a}s Szab{\'o} and Joanne Uhl and S Pesian and A Schmutz and Heinrich E. Schmidt-Gayk and Eberhard Ritz},
  journal={Kidney international},
  year={1993},
  volume={44 6},
  pages={1259-65}
}
Conflicting results have been reported regarding the efficacy of intermittent versus continuous administration of 1,25(OH)2D3 in renal secondary hyperparathyroidism. To address this issue we examined sham-operated control rats and hyperparathyroid rats with subtotal (5/6) nephrectomy (Nx). The Nx animals (20 to 22 animals per group) were subjected to three treatment protocols: (i) solvent treatment (Nx-solvent); (ii) two i.p. injections of 35 pmol 1,25(OH)2D3 on days 0 and 4 (Nx-bolus); and… CONTINUE READING

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