Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch‐regulation in nonsingers

@article{Finkel2019IntermittentTB,
  title={Intermittent theta burst stimulation over right somatosensory larynx cortex enhances vocal pitch‐regulation in nonsingers},
  author={Sebastian Finkel and Ralf Veit and Martin Lotze and Anders Friberg and Peter Vuust and Surjo Raphael Soekadar and Niels Birbaumer and Boris Kleber},
  journal={Human Brain Mapping},
  year={2019},
  volume={40},
  pages={2174 - 2187}
}
While the significance of auditory cortical regions for the development and maintenance of speech motor coordination is well established, the contribution of somatosensory brain areas to learned vocalizations such as singing is less well understood. To address these mechanisms, we applied intermittent theta burst stimulation (iTBS), a facilitatory repetitive transcranial magnetic stimulation (rTMS) protocol, over right somatosensory larynx cortex (S1) and a nonvocal dorsal S1 control area in… 

Top-Down Inhibitory Mechanisms Underlying Auditory-Motor Integration for Voice Control: Evidence by TMS.

The dorsolateral prefrontal cortex (DLPFC) has been implicated in auditory-motor integration for accurate control of vocal production, but its precise role in this feedback-based process remains

Singing training predicts increased insula connectivity with speech and respiratory sensorimotor areas at rest

Results indicate enhanced bilateral insula connectivity in singers relative to non-singers with constituents of the speech sensorimotor network in both hemispheres and suggest that singing experience enhances the integration of somatosensory information within the speech motor system.

Enhanced insular connectivity with speech sensorimotor regions in trained singers: a resting-state fMRI study

The results of this study support the view that the insula plays a central role in the experience-dependent modulation of sensory integration within the vocal motor system, possibly by optimizing conscious and non-conscious aspects of salience processing associated with singing-related bodily signals.

Singers show enhanced performance and neural representation of vocal imitation

It is found that singers showed more accurate task-relevant modulations of speech pitch and VTL during speech imitation; this was accompanied by stronger representation of VTL within a region of the right somatosensory cortex, suggesting a common neural basis for enhanced vocal control in speech and song.

Mapping Human Laryngeal Motor Cortex during Vocalization

Structural and quantitative neuroimaging revealed that myelin content and cortical thickness underlying the dorsal, but not the ventral larynx representation, are similar to those of other primary motor representations.

Two cortical representations of voice control are differentially involved in speech fluency

A weaker structural organization of the ventral laryngeal motor cortical network in developmental stuttering is substantiated and implies that assisted recovery supports neural compensation rather than normalization.

References

SHOWING 1-10 OF 138 REFERENCES

Functional role of delta and theta band oscillations for auditory feedback processing during vocal pitch motor control

It is proposed that the evoked theta is a neurophysiological marker of enhanced pitch processing in musicians and reflects mechanisms by which humans incorporate auditory feedback to control their voice pitch.

Bihemispheric network dynamics coordinating vocal feedback control

Correlation of HGP with behavioral compensation demonstrated right frontal region involvement in modulating participant's compensatory response, highlighting the bihemispheric sensorimotor cortical network involvement in auditory feedback‐based control of vocal pitch.

Experience-Dependent Modulation of Feedback Integration during Singing: Role of the Right Anterior Insula

It is concluded that the right anterior insular cortex and sensory-motor areas play a role in experience-dependent modulation of feedback integration for vocal motor control during singing.

Neural Correlates of Vocal Production and Motor Control in Human Heschl's Gyrus

A functional parcellation of HG with neural activity that encodes pitch in natural human voice, distinguishes between self-generated and passively heard vocalizations, detects discrepancies between the intended and heard vocalization, and contains information about the resulting behavioral vocal compensations in response to auditory feedback pitch perturbations is demonstrated.

Involvement of the larynx motor area in singing-voice perception: a TMS study†

The right larynx premotor region is functionally involved in singing perception and that sound humanness modulates motor resonance, and reaction times were shorter after stimulation over both sites.

Improvement of tactile perception and enhancement of cortical excitability through intermittent theta burst rTMS over human primary somatosensory cortex

The results demonstrate that iTBS protocols resembling those used in slice preparations for the induction of long-term potentiation are also effective in driving lasting improvements of the perception of touch in human subjects together with an enhancement of cortical excitability.

Neural bases of sensorimotor adaptation in the vocal motor system

The present study used event-related potential (ERP) recordings to investigate the neural mechanisms of sensorimotor adaptation in response to altered auditory feedback (AAF) during vocal production, and suggests that vocal motor adaptation is mediated by sensorsimotor reprogramming of feedforward motor commands through incorporating auditory feedback.

Opposite hemispheric lateralization effects during speaking and singing at motor cortex, insula and cerebellum

Findings corroborate the assumption that the left insula supports the coordination of speech articulation and suggest that the right insula might mediate temporo-spatial control of vocal tract musculature during overt singing.
...