Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate.

@article{Hoekstra2005IntermittentRI,
  title={Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate.},
  author={Monique Hoekstra and Cees J. Haagsma and Cees J A Doelman and Martin van de Laar},
  journal={Annals of the rheumatic diseases},
  year={2005},
  volume={64 1},
  pages={
          141-3
        }
}
  • Monique Hoekstra, Cees J. Haagsma, +1 author Martin van de Laar
  • Published in
    Annals of the rheumatic…
    2005
  • Medicine
  • OBJECTIVES To investigate the effect of higher weekly maintenance dose methotrexate (MTX) (> or =25 mg/week) on plasma homocysteine concentrations in adults with RA. METHODS Patients with RA were treated with high doses of MTX with adjuvant folic acid. Plasma homocysteine was determined at baseline and 1, 2, 4, 8, 12, and 48 hours after subcutaneous MTX administration. Maximum homocysteine concentrations after MTX administration were compared with baseline concentrations. RESULTS Fifteen… CONTINUE READING

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