Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican Children

@inproceedings{Quelhas2011IntermittentPT,
  title={Intermittent preventive treatment with sulfadoxine-pyrimethamine does not modify plasma cytokines and chemokines or intracellular cytokine responses to Plasmodium falciparum in Mozambican Children},
  author={Diana Quelhas and Laura Puyol and Llorenç Quint{\'o} and Tacilta Nhampossa and Elisa Serra-Casas and Eus{\'e}bio V Macete and Pedro Carlos Paulino Aide and Sergi Sanz and John J. Aponte and Denise L. Doolan and Pedro Luis Chas Alonso and Clara Men{\'e}ndez and Carlota Doba{\~n}o},
  booktitle={BMC Immunology},
  year={2011}
}
Cytokines and chemokines are key mediators of anti-malarial immunity. We evaluated whether Intermittent Preventive Treatment in infants with Sulfadoxine-Pyrimethamine (IPTi-SP) had an effect on the acquisition of these cellular immune responses in Mozambican children. Multiple cytokines and chemokines were quantified in plasma by luminex, and antigen-specific cytokine production in whole blood was determined by intracellular cytokine staining and flow cytometry, at ages 5, 9, 12 and 24 months… CONTINUE READING
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