Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.

  title={Intermittent peripheral tissue ischemia during coronary ischemia reduces myocardial infarction through a KATP-dependent mechanism: first demonstration of remote ischemic perconditioning.},
  author={M. R. Schmidt and Morten H. Smerup and Igor E. Konstantinov and Mikiko Shimizu and J Li and Matthew Cheung and Paul A. White and Steen Buus Kristiansen and Keld Ejvind S{\o}rensen and Vladim{\'i}r D{\vz}av{\'i}k and Andrew N. Redington and Rajesh K. Kharbanda},
  journal={American journal of physiology. Heart and circulatory physiology},
  volume={292 4},
Remote ischemic preconditioning reduces myocardial infarction (MI) in animal models. We tested the hypothesis that the systemic protection thus induced is effective when ischemic preconditioning is administered during ischemia (PerC) and before reperfusion and examined the role of the K(+)-dependent ATP (K(ATP)) channel. Twenty 20-kg pigs were randomized (10 in each group) to 40 min of left anterior descending coronary artery occlusion with 120 min of reperfusion. PerC consisted of four 5-min… 

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