Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.

@article{Weinstein2010IntermittentPH,
  title={Intermittent parathyroid hormone administration counteracts the adverse effects of glucocorticoids on osteoblast and osteocyte viability, bone formation, and strength in mice.},
  author={Robert S. Weinstein and Robert L. Jilka and Maria de F{\'a}tima Menezes Santos Almeida and Paula K Roberson and Stavros C Manolagas},
  journal={Endocrinology},
  year={2010},
  volume={151 6},
  pages={2641-9}
}
Glucocorticoids act directly on bone cells to decrease production of osteoblasts and osteoclasts, increase osteoblast and osteocyte apoptosis, and prolong osteoclast life span. Conversely, daily injections of PTH decrease osteoblast and osteocyte apoptosis and increase bone formation and strength. Using a mouse model, we investigated whether the recently demonstrated efficacy of PTH in glucocorticoid-induced bone disease results from the ability of this therapeutic modality to counteract at… CONTINUE READING

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