Intermittent hypoxia is an angiogenic inducer for endothelial cells: role of HIF-1

  title={Intermittent hypoxia is an angiogenic inducer for endothelial cells: role of HIF-1},
  author={S{\'e}bastien Toffoli and Audrey Roegiers and Olivier F{\'e}ron and Martine Van Steenbrugge and No{\"e}lle Ninane and Martine Raes and Carine Michiels},
The presence of hypoxia in tumor and its role in promoting angiogenesis are well-established. Recently, in addition to chronic hypoxia, cycling or intermittent hypoxia has also been demonstrated. However, its role in inducing new blood vessel formation is less clear. This work is aimed to investigate whether intermittent hypoxia can induce a pro-angiogenic phenotype in endothelial cells, in vitro. We studied changes in the expression of genes involved in inflammation and angiogenesis under… CONTINUE READING


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fifteen years later

  • G Gloire, S Legrand-Poels, species Piette J NF-kappaB activation by reactive oxygen
  • Biochem Pharmacol 72:1493–1505. doi:10.1016/j.bcp…
  • 2009
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