Intermittent hypoxia induces NF-κB-dependent endothelial activation via adipocyte-derived mediators.

@article{Lee2016IntermittentHI,
  title={Intermittent hypoxia induces NF-κB-dependent endothelial activation via adipocyte-derived mediators.},
  author={Mary Y K Lee and Yan Wang and Judith C W Mak and Mary SiuMan Ip},
  journal={American journal of physiology. Cell physiology},
  year={2016},
  volume={310 6},
  pages={C446-55}
}
Aberrant release of adipocytokines from adipose tissues dysregulates cardiometabolic functions. The present study hypothesizes that chronic intermittent hypoxia (IH) present in obstructive sleep apnea leads to adipose tissue dysfunction, which in turn contributes to vascular pathogenesis. The effect of IH was evaluated in adipose depots and aortic tissues in lean rats in vivo. Furthermore, the cellular and molecular mechanisms underlying pathophysiological interactions between adipocytes and… CONTINUE READING