Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation.

@article{Makarenko2014IntermittentHE,
  title={Intermittent hypoxia-induced endothelial barrier dysfunction requires ROS-dependent MAP kinase activation.},
  author={Vladislav V. Makarenko and Peter V. Usatyuk and Guoxiang Yuan and May May Lee and Jayasri Nanduri and Viswanathan Natarajan and Ganesh K. Kumar and Nanduri R Prabhakar},
  journal={American journal of physiology. Cell physiology},
  year={2014},
  volume={306 8},
  pages={C745-52}
}
The objective of the present study was to determine the impact of simulated apnea with intermittent hypoxia (IH) on endothelial barrier function and assess the underlying mechanism(s). Experiments were performed on human lung microvascular endothelial cells exposed to IH-consisting alternating cycles of 1.5% O2 for 30s followed by 20% O2 for 5 min. IH decreased transendothelial electrical resistance (TEER) suggesting attenuated endothelial barrier function. The effect of IH on TEER was stimulus… CONTINUE READING

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