Intermittent hypoxia exposure prevents mtDNA deletion and mitochondrial structure damage produced by ischemia/reperfusion injury.

@article{Zhong2000IntermittentHE,
  title={Intermittent hypoxia exposure prevents mtDNA deletion and mitochondrial structure damage produced by ischemia/reperfusion injury.},
  author={Ning Zhong and Yi Ran Zhang and Hai Feng Zhu and Z N Zhou},
  journal={Sheng li xue bao : [Acta physiologica Sinica]},
  year={2000},
  volume={52 5},
  pages={375-80}
}
In the present study, polymerase chain reaction (PCR) was conducted to determine mtDNA(4834) deletion, and myocardial ultrastructure was visualized by electron microscope to see whether intermittent hypoxia (high altitude) adaptation exerts some action on mitochondria against ischemia/reperfusion injury. Myocardial ischemia/reperfusion in isolated perfused rat hearts induced severe damage to the ultrastructure of myocardial mitochondria and mtDNA4834 deletion down to 87.5% of normoxia rats… CONTINUE READING
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