Intermittent fasting and dietary supplementation with 2‐deoxy‐D‐glucose improve functional and metabolic cardiovascular risk factors in rats

@article{Wan2003IntermittentFA,
  title={Intermittent fasting and dietary supplementation with 2‐deoxy‐D‐glucose improve functional and metabolic cardiovascular risk factors in rats},
  author={Ruiqian Wan and Simonetta Camandola and Mark P. Mattson},
  journal={The FASEB Journal},
  year={2003},
  volume={17}
}
Hypertension and insulin resistance syndrome are risk factors for cardiovascular disease, and it is therefore important to identify interventions that can reduce blood pressure and improve glucose metabolism. We performed experiments aimed at determining whether intermittent fasting (IF) can improve cardiovascular health and also tested the hypothesis that beneficial effects of IF can be mimicked by dietary supplementation with 2‐deoxy‐D‐glucose (2DG) a non‐metabolizable glucose analog. Four… Expand
Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats.
TLDR
It is concluded that improvements in some cardiovascular risk factors and stress adaptation in rats maintained on a 2-DG-supplemented diet are associated with reduced neuroendocrine responses to the stressors. Expand
Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats
  • D. Mager, Ruiqian Wan, +4 authors M. Mattson
  • Biology, Medicine
  • FASEB journal : official publication of the Federation of American Societies for Experimental Biology
  • 2006
TLDR
The results suggest an additional cardiovascular benefit of DR that merits further studies of this potential effect in humans, and alter spectral measures of heart rate and blood pressure variability in rats. Expand
The Influence of Intermittent Fasting Regimens on the Regulatory Mechanisms of Metabolic Health
TLDR
Alternative day fasting (ADF) is considered as good protocol of food intake therapy for persons with non -alcoholic fatty liver disease (NAFLD), which can help in loss of weight and treatment of dyslipidemia within a relatively short period of time, and reduce cardiovascular risk factors. Expand
Intermittent Fasting for Twelve Weeks Leads to Increases in Fat Mass and Hyperinsulinemia in Young Female Wistar Rats
TLDR
It is suggested that alternate-day IF promote β -cell dysfunction, especially in developing animals, and more long-term research is necessary to define the best IF protocol to reduce side effects. Expand
Obese mice on a high‐fat alternate‐day fasting regimen lose weight and improve glucose tolerance
TLDR
Collectively, the ADF regimen with a HF diet in obese mice results in weight loss, improved blood glucose control, and daily fluctuations in selected physiological and biochemical parameters in the mouse. Expand
A Comparison of Dietary and Caloric Restriction Models on Body Composition, Physical Performance, and Metabolic Health in Young Mice
TLDR
All investigated fasting protocols may improve body composition, measures of insulin sensitivity, and physical performance compared to a high-fat Western diet, and the DF and ADF protocols are most favorable with regards to insulin sensitivity and glucose tolerance. Expand
Caloric restriction and intermittent fasting alter hepatic lipid droplet proteome and diacylglycerol species and prevent diabetes in NZO mice.
TLDR
Protection against diabetes upon caloric restriction and intermittent fasting associates with a modulation of lipid droplet protein composition and reduction of intracellular DAG species. Expand
Assessment of enhanced endothelium-dependent vasodilation by intermittent fasting in Wistar albino rats.
TLDR
Intermittent fasting reduces weight gain in young male rats and improves their aortic endothelium-dependent vasorelaxation, a type of feeding regimen where the frequency of eating is reduced enhances cardiovascular stress adaptation and improves cardiovascular risk factors in rats. Expand
Metabolic effects of intermittent fasting
TLDR
Combining the acute metabolic effects of substantial energy restriction (ER) in healthy, overweight/obese participants and the effects of a 10-week, three-hour daily shortening of the eating window on fasting metabolism and adiposity utilising a parallel-armed controlled design provide novel insights into the metabolic effects. Expand
Intermittent calorie restriction largely counteracts the adverse health effects of a moderate‐fat diet in aging C57BL/6J mice
Scope: Calorie restriction (CR) has been shown to extend life‐ and health‐span in model species. For most humans, a life‐long CR diet is too arduous to adhere to. The aim of this study was to exploreExpand
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